All You Need to Know About Tribedoce

Tribedoce) refers to a group of water-soluble vitamins. It has a high biological activity. Tribedoce (vitamin B12 (hydroxocobalamin)) is required for normal hematopoiesis (promotes red blood cell maturation). Involved in the processes of transmethylation, hydrogen transport, synthesis of methionine, nucleic acids, choline, creatine. It contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups. It has a beneficial effect on liver function and the nervous system. Activates blood clotting in high doses causes increased activity of thromboplastin and prothrombin.

Pharmacokinetics

After oral administration, Tribedoce (vitamin B12 (hydroxocobalamin)) is absorbed from the gastrointestinal tract. It is metabolized in the tissues and converted to a form of coenzyme: adenosylcobalamin, which is the active form of cyanocobalamin. It is excreted in bile and urine.

Why is Tribedoce) prescribed?

Anemia due to B12 deficiency conditions; in complex therapy for iron and post-hemorrhagic anemia; aplastic anemia caused by toxic substances and drugs; liver disease (hepatitis, cirrhosis); funicular myelosis; polyneuritis, radiculitis, neuralgia, amyotrophic lateral sclerosis; children with cerebral palsy, Down syndrome, peripheral nerve injury; skin diseases (psoriasis, photodermatosis, dermatitis herpetiformis, neurodermatitis); to prevent and treat symptoms of Tribedoce (vitamin B12 (hydroxocobalamin)) deficiency (including the application of biguanide, PASA, vitamin C in high doses); radiation sickness.


Dosage and administration

Tribedoce) is used as SC, IV, IM, intralumbar and oral injections. With anemia associated with Tribedoce (vitamin B12 (hydroxocobalamin)), the deficiency enters 100-200 mcg in 2 days. In anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system: 400-500 micrograms in the first 7 days a day, then 1 time every 5-7 days. In the remission period in the go here absence of events maintenance dose of funicular myelosis - 100 mcg 2 times a month, in the presence of neurological symptoms - to 200-400 mcg 2-4 times a month. In acute post-hemorrhagic anemia and iron anemia by 30-100 mcg 2-3 times a week. When aplastic anemia (especially in children) - 100 micrograms before clinical improvement. When nutritional anemia in infants and premature infants - 30 mcg / day for 15 days.

In diseases of the central and peripheral nervous system and neurological diseases with a pain syndrome it is administered in increasing doses: 200-500 mcg, with improvement in the state: 100 mcg / day. The course of treatment with Tribedoce (vitamin B12 (hydroxocobalamin)) is 2 weeks. In traumatic lesions of the peripheral nervous system: at 200-400 mcg every other day for 40-45 days.

When hepatitis and cirrhosis - 30-60 mcg / day or 100 mg every other day for 25-40 days.

Young Child Dystrophy, Down Syndrome, and Cerebral Palsy: 15-30 mcg every other day.

When funicular myelosis, amyotrophic lateral sclerosis can be introduced into the spinal canal at 15-30 mcg, gradually increasing the dose of 200-250 micrograms.

In radiation sickness, diabetic neuropathy, sprue: 60-100 mcg daily for 20-30 days.

You might be thinking what is Tribedoce deficiency (vitamin B12 (hydroxocobalamin)) to prevent - IV or IM for 1 mg 1 time a month; for treatment - IV or IM for 1 mg per day for 1-2 weeks, maintenance dose is 1-2 mg IV or IM from 1 per week, up to 1 per month. The duration of treatment is determined individually.

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